Natural Product-Based Drug Discovery

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Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?

High-throughput biology has contributed a wealth of data on chemicals, including natural products (NPs). Recently, attention was drawn to certain, predominantly synthetic, compounds that are responsible for disproportionate percentages of hits but are false actives. Spurious bioassay interference led to their designation as pan-assay interference compounds (PAINS). NPs lack comparable scrutiny,...

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ژورنال

عنوان ژورنال: Medicinal Research Reviews

سال: 2015

ISSN: 0198-6325

DOI: 10.1002/med.21380